Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities

J Med Chem. 1993 Aug 20;36(17):2575-7. doi: 10.1021/jm00069a018.

Authors

K T Chong¹, M J Ruwart, R R Hinshaw, K F Wilkinson, B D Rush, M F Yancey, J W Strohbach, S Thaisrivongs

Affiliation

¹ Cancer & Infectious Diseases Research, Upjohn Company, Kalamazoo, Michigan 49001.

PMID: 8355256
DOI: 10.1021/jm00069a018

No abstract available

MeSH terms

Animals
Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacokinetics
Antiviral Agents / pharmacology
HIV Protease Inhibitors / chemical synthesis*
HIV Protease Inhibitors / pharmacology
Half-Life
Humans
Male
Organophosphorus Compounds / chemical synthesis*
Organophosphorus Compounds / pharmacokinetics
Organophosphorus Compounds / pharmacology
Prodrugs / chemical synthesis*
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship

Substances

Antiviral Agents
HIV Protease Inhibitors
Organophosphorus Compounds
Prodrugs